Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2Avg	GS1	5.23e-01	6.02e-01	2.49e-03	2.90e-03
GS1	AC2Avg	9.01e-02	8.13e-01	1.17e-08	1.29e-12



Evaluating how well AC2Avg genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Avg	GS1	0.73	-0.92	0.10	0.29	3.88
GS1	AC2Avg	0.68	-0.23	0.40	0.59	7.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Avg	GS1	0.00	-1.23	-0.69	-0.22	1.48
GS1	AC2Avg	0.01	-0.84	-0.28	0.77	7.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2Avg	173	167	SPI-2;MC159L;CRMA;UL36;TFDP2;ORF71
GS1	20	20