Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2Avg Exclusive	GS3	1.35e-03	6.80e-02	7.14e-04	4.52e-01
GS3 Exclusive	AC2Avg	1.08e-01	4.29e-01	6.19e-02	4.80e-07
AC2Avg Exclusive	GS3 Exclusive	9.93e-04	5.29e-02	5.40e-03	6.33e-01
GS3 Exclusive	AC2Avg Exclusive	7.08e-02	3.34e-01	1.06e-01	3.34e-06
AC2Avg Exclusive	Overlap	1.15e-02	3.22e-02	1.15e-02	1.82e-02
GS3 Exclusive	Overlap	2.12e-01	1.98e-01	7.09e-02	7.69e-02
Overlap	Exclusives	5.60e-02	3.78e-03	1.10e-16	7.98e-20



Evaluating how well AC2Avg genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Avg Exclusive	GS3	0.54	-2.29	-2.31	-1.46	1.33
GS3 Exclusive	AC2Avg	0.63	-1.50	-1.38	-0.36	6.24
AC2Avg Exclusive	GS3 Exclusive	0.53	-2.47	-2.38	-1.86	1.05
GS3 Exclusive	AC2Avg Exclusive	0.63	-1.98	-1.49	-0.53	6.04
AC2Avg Exclusive	Overlap	0.98	1.97	2.10	2.54	2.24
GS3 Exclusive	Overlap	0.81	1.48	1.17	1.17	1.57
Overlap	Exclusives	0.70	1.05	3.89	1.79	11.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Avg Exclusive	GS3	0.01	-0.78	-0.81	0.11	2.40
GS3 Exclusive	AC2Avg	0.01	-1.48	-1.37	-0.24	5.42
AC2Avg Exclusive	GS3 Exclusive	0.00	-1.54	-1.41	-0.71	1.45
GS3 Exclusive	AC2Avg Exclusive	0.01	-1.81	-1.30	-0.42	4.53
AC2Avg Exclusive	Overlap	0.00	5.44	4.38	13.60	8.50
GS3 Exclusive	Overlap	0.00	0.56	0.05	-0.02	0.25
Overlap	Exclusives	0.03	3.78	9.20	4.81	20.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2Avg Exclusive	171	165	CRMA;UL36;MC159L;TFDP2;ORF71;SPI-2
GS3 Exclusive	77	76	CASC16
Overlap	2	2