Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC3Avg	GS1	8.80e-01	8.23e-01	2.17e-04	3.45e-04
GS1	AC3Avg	1.19e-02	5.77e-01	4.89e-10	7.70e-13



Evaluating how well AC3Avg genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Avg	GS1	0.74	-1.28	-0.10	0.69	3.82
GS1	AC3Avg	0.70	-0.76	0.50	1.06	8.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Avg	GS1	0.00	-1.52	-1.27	0.60	0.20
GS1	AC3Avg	0.02	-0.79	0.08	2.16	7.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC3Avg	154	149	ORF71;MC159L;TFDP2;CRMA;SPI-2
GS1	20	20