Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4	GS1	3.95e-01	9.30e-01	2.07e-03	2.14e-03
GS1	AC4	6.05e-03	3.85e-01	1.68e-05	1.59e-09



Evaluating how well AC4 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4	GS1	0.70	-2.64	-0.98	-0.08	3.22
GS1	AC4	0.66	-1.34	-2.01	0.03	6.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4	GS1	0.00	-2.10	-1.04	-0.28	0.83
GS1	AC4	0.01	-1.05	-1.45	0.56	5.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4	140	139	TFDP2
GS1	20	20