Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC5	GS2	1.18e-01	7.20e-01	2.57e-02	1.36e-01
GS2	AC5	1.07e-01	6.77e-01	1.11e-02	4.14e-05



Evaluating how well AC5 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC5	GS2	0.60	-1.53	-1.11	-0.40	1.88
GS2	AC5	0.62	-1.11	-1.26	-0.11	5.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC5	GS2	0.00	-1.01	-0.85	0.14	1.34
GS2	AC5	0.01	-1.28	-1.35	0.27	3.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC5	165	164	TFDP2
GS2	29	27	LOC100131289;WNT3