Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC7	GS1	4.02e-01	9.26e-01	4.76e-04	1.75e-02
GS1	AC7	2.59e-01	5.53e-01	1.33e-05	4.24e-10



Evaluating how well AC7 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7	GS1	0.70	-2.52	-0.01	0.22	3.01
GS1	AC7	0.75	0.09	-0.26	0.58	6.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7	GS1	0.00	-1.43	-0.37	0.23	0.48
GS1	AC7	0.01	-0.48	-1.52	0.42	3.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC7	63	61	MIR137;MIR132
GS1	20	20