Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC7 Exclusive	GS2	4.69e-01	8.98e-01	4.59e-03	1.31e-01
GS2 Exclusive	AC7	5.92e-01	9.46e-02	1.13e-04	4.19e-14
AC7 Exclusive	GS2 Exclusive	4.80e-01	9.29e-01	1.28e-02	1.32e-01
GS2 Exclusive	AC7 Exclusive	5.55e-01	1.15e-01	1.20e-04	1.16e-12
AC7 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
GS2 Exclusive	Overlap	3.51e-01	2.17e-01	1.66e-01	1.75e-01
Overlap	Exclusives	1.78e-09	1.52e-04	1.92e-21	3.13e-21



Evaluating how well AC7 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7 Exclusive	GS2	0.62	-0.57	0.11	0.67	2.33
GS2 Exclusive	AC7	0.77	-0.02	2.43	1.06	7.24
AC7 Exclusive	GS2 Exclusive	0.61	-0.74	-0.18	0.15	1.69
GS2 Exclusive	AC7 Exclusive	0.77	-0.18	1.98	1.00	7.66
AC7 Exclusive	Overlap	0.99	1.55	1.87	2.15	1.82
GS2 Exclusive	Overlap	0.89	0.89	1.24	1.37	1.39
Overlap	Exclusives	0.83	2.15	6.12	2.32	10.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7 Exclusive	GS2	0.00	0.71	1.33	3.57	0.27
GS2 Exclusive	AC7	0.01	-0.56	0.83	0.54	4.72
AC7 Exclusive	GS2 Exclusive	0.00	-0.05	-0.49	1.15	0.09
GS2 Exclusive	AC7 Exclusive	0.01	-0.53	0.39	0.66	5.91
AC7 Exclusive	Overlap	0.00	12.74	47.29	14.21	19.92
GS2 Exclusive	Overlap	0.00	-0.04	0.18	0.55	1.00
Overlap	Exclusives	0.02	5.56	14.85	4.52	12.59

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC7 Exclusive	62	60	MIR137;MIR132
GS2 Exclusive	28	26	LOC100131289;WNT3 
Overlap	1	1