Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC7 Exclusive	GS3	1.63e-01	2.73e-01	2.13e-04	9.51e-02
GS3 Exclusive	AC7	5.38e-01	8.31e-02	3.38e-04	9.50e-14
AC7 Exclusive	GS3 Exclusive	1.32e-01	2.54e-01	4.26e-04	1.76e-01
GS3 Exclusive	AC7 Exclusive	4.60e-01	8.58e-02	6.32e-04	5.88e-14
AC7 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
GS3 Exclusive	Overlap	1.41e-01	6.11e-01	8.11e-01	5.50e-01
Overlap	Exclusives	2.54e-07	1.15e-02	5.76e-19	4.78e-18



Evaluating how well AC7 genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7 Exclusive	GS3	0.57	-0.78	-0.92	-0.05	2.34
GS3 Exclusive	AC7	0.77	0.10	1.54	1.25	7.00
AC7 Exclusive	GS3 Exclusive	0.57	-0.68	-0.74	-0.23	1.81
GS3 Exclusive	AC7 Exclusive	0.77	0.44	2.02	1.16	7.35
AC7 Exclusive	Overlap	0.99	1.55	1.90	1.93	1.85
GS3 Exclusive	Overlap	0.60	-1.38	-0.30	-0.29	0.38
Overlap	Exclusives	0.75	2.45	4.86	2.43	10.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7 Exclusive	GS3	0.01	0.20	0.05	1.45	2.42
GS3 Exclusive	AC7	0.01	-0.86	0.08	0.69	5.72
AC7 Exclusive	GS3 Exclusive	0.01	-0.38	-0.21	0.48	1.13
GS3 Exclusive	AC7 Exclusive	0.01	-0.63	0.28	0.53	9.44
AC7 Exclusive	Overlap	0.00	3.04	47.66	41.91	0.17
GS3 Exclusive	Overlap	0.00	-0.56	-0.57	-0.41	-0.29
Overlap	Exclusives	0.02	4.35	6.83	3.41	11.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC7 Exclusive	62	60	MIR132;MIR137
GS3 Exclusive	78	77	CASC16
Overlap	1	1