Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC8	GS1	7.10e-01	5.68e-01	7.05e-02	4.18e-04
GS1	AC8	6.35e-03	9.98e-03	1.51e-02	9.68e-03



Evaluating how well AC8 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8	GS1	0.74	-0.14	1.13	0.57	3.55
GS1	AC8	0.51	-2.13	-2.86	-0.72	0.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8	GS1	0.00	-1.33	-0.75	-0.33	2.67
GS1	AC8	0.01	-0.91	-0.91	-0.13	1.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC8	176	169	env;DEFB117;DEFB109B;PRSS2;DEFB108P1;DEFB130B;MIR132
GS1	20	20