Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC8 Exclusive	GS2	5.79e-01	4.08e-01	3.70e-01	1.13e-02
GS2 Exclusive	AC8	9.22e-01	1.61e-01	2.39e-04	1.57e-03
AC8 Exclusive	GS2 Exclusive	4.68e-01	4.83e-01	6.13e-01	1.30e-02
GS2 Exclusive	AC8 Exclusive	8.53e-01	1.68e-01	3.27e-03	2.67e-03
AC8 Exclusive	Overlap	9.92e-02	1.41e-01	9.92e-02	1.12e-01
GS2 Exclusive	Overlap	2.78e-01	1.66e-01	1.41e-01	1.75e-01
Overlap	Exclusives	3.84e-04	1.32e-02	3.18e-15	2.73e-09



Evaluating how well AC8 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8 Exclusive	GS2	0.65	0.85	1.31	0.80	2.39
GS2 Exclusive	AC8	0.55	0.13	-0.25	0.44	2.58
AC8 Exclusive	GS2 Exclusive	0.64	0.49	0.86	0.51	2.52
GS2 Exclusive	AC8 Exclusive	0.55	0.24	-0.19	0.16	2.42
AC8 Exclusive	Overlap	0.96	1.52	1.36	1.72	1.60
GS2 Exclusive	Overlap	0.89	0.86	1.26	1.50	1.20
Overlap	Exclusives	0.58	0.22	0.14	0.19	3.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8 Exclusive	GS2	0.00	0.24	0.55	0.33	2.03
GS2 Exclusive	AC8	0.01	-0.27	0.48	0.46	3.78
AC8 Exclusive	GS2 Exclusive	0.00	-0.25	-0.06	-0.01	0.96
GS2 Exclusive	AC8 Exclusive	0.01	-0.26	0.37	0.23	2.70
AC8 Exclusive	Overlap	0.00	5.26	0.50	4.47	2.80
GS2 Exclusive	Overlap	0.00	-0.07	0.32	0.79	0.40
Overlap	Exclusives	0.02	0.66	5.54	0.47	8.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC8 Exclusive	175	168	DEFB117;DEFB108P1;DEFB130B;MIR132;PRSS2;DEFB109B;env
GS2 Exclusive	28	26	LOC100131289;WNT3 
Overlap	1	1