Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC8 Exclusive	GS3	1.24e-02	8.70e-01	6.33e-02	1.14e-01
GS3 Exclusive	AC8	9.08e-01	9.18e-01	9.02e-03	2.24e-03
AC8 Exclusive	GS3 Exclusive	1.31e-02	9.25e-01	1.21e-01	2.36e-01
GS3 Exclusive	AC8 Exclusive	9.38e-01	9.18e-01	1.83e-03	1.90e-03
AC8 Exclusive	Overlap	9.92e-02	1.25e-01	9.92e-02	1.25e-01
GS3 Exclusive	Overlap	1.66e-01	5.90e-01	7.14e-01	6.52e-01
Overlap	Exclusives	1.15e-03	7.10e-02	1.68e-19	8.74e-10



Evaluating how well AC8 genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8 Exclusive	GS3	0.57	-1.20	-0.17	-0.52	2.06
GS3 Exclusive	AC8	0.56	0.10	0.05	0.28	2.95
AC8 Exclusive	GS3 Exclusive	0.56	-1.40	-0.53	-0.81	1.62
GS3 Exclusive	AC8 Exclusive	0.56	0.26	-0.14	0.65	2.79
AC8 Exclusive	Overlap	0.96	1.81	1.32	1.74	1.60
GS3 Exclusive	Overlap	0.60	-1.34	-0.29	-0.14	0.35
Overlap	Exclusives	0.59	0.13	0.92	0.57	4.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8 Exclusive	GS3	0.01	-0.59	0.02	0.08	1.73
GS3 Exclusive	AC8	0.01	-0.78	-0.15	-0.04	3.38
AC8 Exclusive	GS3 Exclusive	0.01	-0.81	-0.17	-0.28	1.27
GS3 Exclusive	AC8 Exclusive	0.01	-0.54	-0.26	0.38	3.70
AC8 Exclusive	Overlap	0.00	7.68	0.71	1.47	0.29
GS3 Exclusive	Overlap	0.00	-0.52	-0.54	-0.38	-0.34
Overlap	Exclusives	0.02	0.56	4.23	1.50	8.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC8 Exclusive	175	168	DEFB108P1;PRSS2;DEFB130B;DEFB109B;MIR132;env;DEFB117
GS3 Exclusive	78	77	CASC16
Overlap	1	1