Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2Med	GS1	2.54e-01	8.62e-01	1.52e-02	3.20e-03
GS1	AC2Med	1.13e-02	7.25e-01	9.45e-12	1.29e-10



Evaluating how well AC2Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Med	GS1	0.72	-1.50	-0.76	-0.22	3.25
GS1	AC2Med	0.66	-0.44	0.95	0.61	8.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Med	GS1	0.00	-1.38	-1.06	-0.30	0.14
GS1	AC2Med	0.02	-1.19	0.58	0.87	7.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2Med	213	207	TFDP2;SPI-2;UGT2A1;CRMA;MC159L;ORF71
GS1	20	20