Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2Med Exclusive	GS3	1.20e-02	4.71e-01	1.14e-03	3.23e-02
GS3 Exclusive	AC2Med	7.43e-03	3.38e-02	4.09e-03	3.73e-05
AC2Med Exclusive	GS3 Exclusive	4.21e-03	3.40e-01	3.63e-03	8.77e-02
GS3 Exclusive	AC2Med Exclusive	1.89e-02	3.07e-02	2.43e-03	4.00e-05
AC2Med Exclusive	Overlap	3.02e-01	9.79e-02	5.04e-02	2.04e-01
GS3 Exclusive	Overlap	7.92e-01	9.70e-01	8.16e-01	9.27e-01
Overlap	Exclusives	9.98e-05	7.88e-08	1.46e-03	2.21e-19



Evaluating how well AC2Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Med Exclusive	GS3	0.57	-0.71	-0.85	-0.36	2.55
GS3 Exclusive	AC2Med	0.61	-1.69	-2.33	-0.44	5.70
AC2Med Exclusive	GS3 Exclusive	0.57	-1.51	-1.22	-0.87	1.80
GS3 Exclusive	AC2Med Exclusive	0.61	-1.30	-2.48	-0.37	4.94
AC2Med Exclusive	Overlap	0.81	3.16	2.08	1.98	1.61
GS3 Exclusive	Overlap	0.54	0.38	0.16	0.11	0.29
Overlap	Exclusives	0.69	1.12	6.23	1.39	10.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Med Exclusive	GS3	0.01	-1.95	-1.36	-0.60	1.64
GS3 Exclusive	AC2Med	0.02	-1.58	-1.42	-0.05	4.97
AC2Med Exclusive	GS3 Exclusive	0.00	-2.51	-1.85	-0.89	0.98
GS3 Exclusive	AC2Med Exclusive	0.02	-1.29	-1.40	-0.03	5.95
AC2Med Exclusive	Overlap	0.00	13.63	0.53	0.10	1.25
GS3 Exclusive	Overlap	0.00	-0.03	-0.19	-0.26	-0.13
Overlap	Exclusives	0.03	0.93	10.59	1.58	17.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2Med Exclusive	211	205	MC159L;ORF71;TFDP2;CRMA;UGT2A1;SPI-2
GS3 Exclusive	77	76	CASC16
Overlap	2	2