Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC3Med	GS1	1.15e-02	9.86e-02	1.89e-04	4.49e-05
GS1	AC3Med	2.93e-04	3.15e-07	2.88e-18	2.36e-15



Evaluating how well AC3Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Med	GS1	0.82	1.67	2.55	1.94	4.81
GS1	AC3Med	0.70	2.89	5.78	2.61	9.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Med	GS1	0.00	0.42	4.61	3.45	6.46
GS1	AC3Med	0.02	2.75	8.41	3.74	9.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC3Med	176	171	CRMA;ORF71;SPI-2;UGT2A1;MC159L
GS1	20	20