Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC3Med	GS2	3.49e-01	8.11e-01	6.94e-02	9.26e-02
GS2	AC3Med	2.22e-01	8.91e-02	1.13e-04	6.53e-04



Evaluating how well AC3Med genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Med	GS2	0.63	-0.08	0.30	0.23	1.97
GS2	AC3Med	0.60	-0.30	-0.34	-0.15	4.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Med	GS2	0.00	-0.31	0.41	0.33	0.26
GS2	AC3Med	0.01	0.25	1.47	0.35	4.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC3Med	176	171	ORF71;CRMA;MC159L;SPI-2;UGT2A1
GS2	29	27	LOC100131289;WNT3