Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1Med Exclusive	GS3	5.85e-02	8.43e-01	2.16e-03	5.54e-02
GS3 Exclusive	AC1Med	1.33e-01	4.79e-01	5.96e-04	4.38e-04
AC1Med Exclusive	GS3 Exclusive	2.30e-02	7.03e-01	1.87e-02	3.77e-02
GS3 Exclusive	AC1Med Exclusive	5.72e-02	4.00e-01	1.28e-03	2.64e-04
AC1Med Exclusive	Overlap	1.60e-03	3.54e-03	1.53e-03	6.85e-03
GS3 Exclusive	Overlap	3.00e-01	3.72e-01	1.41e-01	3.47e-01
Overlap	Exclusives	3.29e-18	9.12e-22	2.50e-18	1.86e-36



Evaluating how well AC1Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Med Exclusive	GS3	0.60	0.56	0.16	0.53	2.65
GS3 Exclusive	AC1Med	0.59	-0.29	-0.22	0.02	4.43
AC1Med Exclusive	GS3 Exclusive	0.58	-0.50	-0.33	-0.27	2.53
GS3 Exclusive	AC1Med Exclusive	0.59	-0.66	-0.34	0.08	5.08
AC1Med Exclusive	Overlap	0.95	4.49	3.72	3.75	2.56
GS3 Exclusive	Overlap	0.69	1.45	1.18	1.48	1.17
Overlap	Exclusives	0.75	3.11	11.98	3.36	14.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Med Exclusive	GS3	0.01	0.33	0.45	0.58	2.79
GS3 Exclusive	AC1Med	0.02	-0.27	1.60	0.85	5.01
AC1Med Exclusive	GS3 Exclusive	0.01	-0.82	-0.59	-0.35	1.81
GS3 Exclusive	AC1Med Exclusive	0.02	-0.76	0.83	0.44	6.55
AC1Med Exclusive	Overlap	0.00	52.44	35.68	21.92	4.82
GS3 Exclusive	Overlap	0.03	58.41	147.65	33.73	49.36
Overlap	Exclusives	0.05	8.80	31.74	8.90	37.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1Med Exclusive	228	224	MC159L;TFDP2;UGT2A1;ORF71
GS3 Exclusive	76	75	CASC16
Overlap	3	3