Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC3Med Exclusive	GS3	1.85e-03	3.72e-01	1.33e-03	3.68e-02
GS3 Exclusive	AC3Med	1.89e-02	1.65e-02	1.00e-06	9.47e-06
AC3Med Exclusive	GS3 Exclusive	1.25e-03	2.59e-01	4.71e-03	1.16e-01
GS3 Exclusive	AC3Med Exclusive	2.05e-02	2.54e-02	8.32e-08	1.17e-05
AC3Med Exclusive	Overlap	1.49e-02	2.67e-02	1.42e-02	5.04e-02
GS3 Exclusive	Overlap	7.66e-01	9.10e-01	7.54e-01	8.82e-01
Overlap	Exclusives	8.27e-07	1.29e-06	5.64e-05	1.34e-17



Evaluating how well AC3Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Med Exclusive	GS3	0.59	0.02	0.04	0.32	2.69
GS3 Exclusive	AC3Med	0.60	-0.22	-0.70	0.22	4.95
AC3Med Exclusive	GS3 Exclusive	0.58	-0.37	-0.42	-0.22	2.31
GS3 Exclusive	AC3Med Exclusive	0.60	0.08	-0.50	0.48	4.36
AC3Med Exclusive	Overlap	0.92	3.58	2.93	2.51	1.93
GS3 Exclusive	Overlap	0.54	0.56	0.16	0.29	0.32
Overlap	Exclusives	0.68	2.00	6.80	2.19	11.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3Med Exclusive	GS3	0.01	0.00	1.51	1.17	1.20
GS3 Exclusive	AC3Med	0.01	1.19	4.13	2.31	8.62
AC3Med Exclusive	GS3 Exclusive	0.01	-0.17	0.74	0.58	2.69
GS3 Exclusive	AC3Med Exclusive	0.01	1.78	3.55	2.74	6.29
AC3Med Exclusive	Overlap	0.00	12.22	0.56	2.50	0.45
GS3 Exclusive	Overlap	0.00	-0.10	-0.24	-0.17	-0.11
Overlap	Exclusives	0.03	2.14	11.22	3.78	15.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC3Med Exclusive	174	169	CRMA;ORF71;MC159L;SPI-2;UGT2A1
GS3 Exclusive	77	76	CASC16
Overlap	2	2