Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1Med Exclusive	GS3	5.57e-02	9.03e-01	1.51e-03	3.49e-02
GS3 Exclusive	AC1Med	4.34e-02	4.50e-01	4.21e-04	3.30e-04
AC1Med Exclusive	GS3 Exclusive	2.88e-02	7.57e-01	2.86e-02	3.60e-02
GS3 Exclusive	AC1Med Exclusive	1.20e-01	3.95e-01	2.51e-03	6.05e-04
AC1Med Exclusive	Overlap	1.76e-03	4.05e-03	1.45e-03	8.12e-03
GS3 Exclusive	Overlap	2.86e-01	3.55e-01	1.54e-01	3.08e-01
Overlap	Exclusives	8.13e-19	2.74e-22	3.44e-20	1.12e-36



Evaluating how well AC1Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Med Exclusive	GS3	0.60	0.47	0.33	0.29	3.09
GS3 Exclusive	AC1Med	0.59	-0.66	-0.21	0.09	5.08
AC1Med Exclusive	GS3 Exclusive	0.58	-0.42	-0.27	-0.41	2.76
GS3 Exclusive	AC1Med Exclusive	0.59	-0.42	-0.35	-0.07	4.25
AC1Med Exclusive	Overlap	0.95	4.73	2.96	3.53	2.64
GS3 Exclusive	Overlap	0.69	1.29	1.07	1.38	1.16
Overlap	Exclusives	0.75	3.28	12.99	3.05	14.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Med Exclusive	GS3	0.01	0.26	0.46	0.62	2.68
GS3 Exclusive	AC1Med	0.02	-0.56	1.97	0.81	6.42
AC1Med Exclusive	GS3 Exclusive	0.01	-1.02	-0.49	-0.58	1.54
GS3 Exclusive	AC1Med Exclusive	0.02	-0.67	1.04	0.33	4.34
AC1Med Exclusive	Overlap	0.00	32.07	19.22	27.53	6.77
GS3 Exclusive	Overlap	0.03	130.91	191.64	181.14	63.25
Overlap	Exclusives	0.05	9.58	33.55	6.27	30.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1Med Exclusive	228	224	ORF71;UGT2A1;TFDP2;MC159L
GS3 Exclusive	76	75	CASC16
Overlap	3	3