Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4Med Exclusive	GS3	2.28e-05	6.96e-03	6.88e-04	2.39e-01
GS3 Exclusive	AC4Med	1.43e-04	6.06e-02	7.54e-02	5.32e-04
AC4Med Exclusive	GS3 Exclusive	4.74e-06	3.48e-03	1.18e-03	3.06e-01
GS3 Exclusive	AC4Med Exclusive	6.41e-04	2.46e-02	1.07e-01	1.01e-03
AC4Med Exclusive	Overlap	5.74e-02	6.52e-02	4.23e-02	1.10e-01
GS3 Exclusive	Overlap	9.01e-01	9.27e-01	8.04e-01	9.10e-01
Overlap	Exclusives	2.67e-06	3.45e-07	9.02e-03	1.43e-19



Evaluating how well AC4Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4Med Exclusive	GS3	0.52	-2.97	-2.56	-2.07	0.75
GS3 Exclusive	AC4Med	0.59	-2.07	-2.05	-0.73	3.98
AC4Med Exclusive	GS3 Exclusive	0.52	-4.23	-2.76	-2.82	0.51
GS3 Exclusive	AC4Med Exclusive	0.59	-1.84	-2.58	-1.02	3.93
AC4Med Exclusive	Overlap	0.84	3.22	2.57	1.96	1.91
GS3 Exclusive	Overlap	0.54	0.44	0.25	0.23	0.27
Overlap	Exclusives	0.70	3.00	6.78	2.38	11.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4Med Exclusive	GS3	0.00	-1.55	-1.22	-0.94	0.10
GS3 Exclusive	AC4Med	0.01	-1.70	-1.06	-0.49	3.44
AC4Med Exclusive	GS3 Exclusive	0.00	-1.99	-1.47	-1.35	0.61
GS3 Exclusive	AC4Med Exclusive	0.01	-1.35	-1.25	-0.70	3.71
AC4Med Exclusive	Overlap	0.00	14.32	2.16	2.95	4.33
GS3 Exclusive	Overlap	0.00	-0.03	-0.20	-0.18	-0.19
Overlap	Exclusives	0.03	4.10	11.44	2.68	16.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4Med Exclusive	182	177	UGT2A1;MC159L;CRMA;ORF71;SPI-2
GS3 Exclusive	77	76	CASC16
Overlap	2	2