Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC5Med	GS2	1.34e-02	3.39e-01	2.31e-01	1.75e-01
GS2	AC5Med	4.41e-02	6.61e-03	8.53e-03	7.67e-04



Evaluating how well AC5Med genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC5Med	GS2	0.59	-1.19	-1.41	-0.69	1.67
GS2	AC5Med	0.56	-1.11	-2.71	-0.74	3.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC5Med	GS2	0.00	-1.12	-0.92	-0.61	0.13
GS2	AC5Med	0.01	-0.70	-1.20	-0.35	2.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC5Med	192	187	UGT2A1;CRMA;SPI-2;MC159L;ORF71
GS2	29	27	WNT3 ;LOC100131289