Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC5Med Exclusive	GS3	1.23e-05	1.42e-01	8.95e-03	2.29e-01
GS3 Exclusive	AC5Med	2.16e-03	4.39e-03	1.50e-01	3.42e-03
AC5Med Exclusive	GS3 Exclusive	3.48e-06	7.99e-02	9.89e-03	2.31e-01
GS3 Exclusive	AC5Med Exclusive	4.50e-04	2.75e-03	2.24e-01	3.76e-03
AC5Med Exclusive	Overlap	5.50e-02	7.39e-02	4.62e-02	1.28e-01
GS3 Exclusive	Overlap	7.79e-01	9.19e-01	7.01e-01	9.27e-01
Overlap	Exclusives	5.69e-08	5.55e-11	2.61e-05	3.93e-22



Evaluating how well AC5Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC5Med Exclusive	GS3	0.53	-2.56	-2.23	-1.83	0.98
GS3 Exclusive	AC5Med	0.55	-1.57	-3.30	-1.27	2.15
AC5Med Exclusive	GS3 Exclusive	0.52	-3.01	-2.65	-2.53	0.72
GS3 Exclusive	AC5Med Exclusive	0.55	-2.00	-3.45	-1.29	2.31
AC5Med Exclusive	Overlap	0.85	3.10	2.12	2.32	1.49
GS3 Exclusive	Overlap	0.54	0.51	0.17	0.36	0.23
Overlap	Exclusives	0.71	2.33	8.17	2.48	11.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC5Med Exclusive	GS3	0.00	-1.75	-1.29	-1.18	-0.00
GS3 Exclusive	AC5Med	0.01	-1.35	-2.43	-0.80	1.09
AC5Med Exclusive	GS3 Exclusive	0.00	-2.45	-1.68	-1.61	-0.03
GS3 Exclusive	AC5Med Exclusive	0.01	-1.66	-1.91	-0.81	1.46
AC5Med Exclusive	Overlap	0.00	5.59	0.27	1.35	-0.07
GS3 Exclusive	Overlap	0.00	0.25	-0.22	-0.10	-0.21
Overlap	Exclusives	0.03	1.89	12.65	4.02	17.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC5Med Exclusive	190	185	UGT2A1;SPI-2;CRMA;ORF71;MC159L
GS3 Exclusive	77	76	CASC16
Overlap	2	2