Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC7Med	GS1	1.31e-01	3.29e-01	2.91e-01	2.90e-04
GS1	AC7Med	7.08e-07	3.58e-02	6.53e-07	1.22e-04



Evaluating how well AC7Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7Med	GS1	0.73	0.36	0.94	0.71	3.95
GS1	AC7Med	0.58	-1.81	-2.62	-0.15	2.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC7Med	GS1	0.00	-0.48	-0.59	0.09	1.18
GS1	AC7Med	0.01	-0.90	-1.71	-0.17	0.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC7Med	93	91	HLA-DRB3;HLA-DRB4
GS1	20	20