Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC8Med	GS1	2.07e-02	4.04e-02	3.77e-03	2.99e-03
GS1	AC8Med	1.50e-06	8.08e-05	4.54e-01	2.72e-11



Evaluating how well AC8Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8Med	GS1	0.68	0.26	1.50	0.20	2.66
GS1	AC8Med	0.30	-2.74	-4.62	-0.92	-5.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8Med	GS1	0.00	-0.30	0.08	-0.53	0.34
GS1	AC8Med	0.00	-1.35	-1.84	-0.41	-2.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC8Med	95	89	PRSS2;DEFB109B;DEFB108P1;DEFB117;DEFB130B;env
GS1	20	20