Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC8Med	GS3	1.32e-07	9.97e-01	1.07e-10	1.73e-01
GS3	AC8Med	8.98e-01	6.21e-01	1.76e-01	6.38e-03



Evaluating how well AC8Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8Med	GS3	0.55	-0.79	-0.31	-0.78	1.52
GS3	AC8Med	0.42	-0.01	-0.36	0.15	-2.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC8Med	GS3	0.00	-0.49	-0.23	-0.58	0.90
GS3	AC8Med	0.00	-0.27	-0.82	-0.30	-1.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC8Med	95	89	DEFB109B;PRSS2;DEFB108P1;DEFB130B;DEFB117;env
GS3	79	78	CASC16