Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC9Med	GS1	8.50e-02	1.13e-01	5.19e-01	1.44e-03
GS1	AC9Med	1.11e-04	1.11e-06	1.35e-13	7.23e-09



Evaluating how well AC9Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC9Med	GS1	0.73	0.58	2.21	0.96	3.45
GS1	AC9Med	0.73	2.96	6.22	2.00	6.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC9Med	GS1	0.00	1.92	4.20	2.82	6.04
GS1	AC9Med	0.01	1.85	4.08	0.87	6.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC9Med	59	59	
GS1	20	20