Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC9Med	GS2	2.52e-04	2.18e-01	1.67e-03	3.89e-03
GS2	AC9Med	1.47e-03	2.35e-02	4.35e-01	8.02e-02



Evaluating how well AC9Med genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC9Med	GS2	0.58	-0.44	-0.29	-0.54	1.59
GS2	AC9Med	0.45	-1.64	-3.99	-1.13	-1.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC9Med	GS2	0.00	-0.80	-0.82	-0.90	0.06
GS2	AC9Med	0.00	-0.91	-1.52	-0.62	-1.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC9Med	59	59	
GS2	29	27	WNT3 ;LOC100131289