Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC9Med	GS3	1.59e-09	2.49e-01	3.97e-07	3.87e-02
GS3	AC9Med	3.77e-02	4.52e-03	5.35e-01	3.77e-02



Evaluating how well AC9Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC9Med	GS3	0.55	-1.04	-0.62	-0.87	1.61
GS3	AC9Med	0.44	-1.17	-3.95	-1.02	-1.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC9Med	GS3	0.00	-0.83	-0.85	-0.95	0.29
GS3	AC9Med	0.00	-0.94	-2.02	-0.62	-1.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC9Med	59	59	
GS3	79	78	CASC16