Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC10Med	GS3	3.92e-07	1.88e-01	2.03e-06	4.04e-01
GS3	AC10Med	3.26e-01	5.23e-01	1.61e-01	5.80e-02



Evaluating how well AC10Med genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC10Med	GS3	0.54	-1.73	-0.83	-1.07	1.26
GS3	AC10Med	0.45	-0.42	-1.30	0.11	-1.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC10Med	GS3	0.00	-1.27	-0.47	-0.93	0.19
GS3	AC10Med	0.01	-0.93	-1.31	-0.52	-0.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC10Med	119	113	DEFB130B;env;DEFB109B;DEFB108P1;DEFB117;PRSS2
GS3	79	78	CASC16