Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC10Med	GS2	8.83e-03	6.35e-01	1.22e-02	5.64e-02
GS2	AC10Med	3.27e-01	4.22e-02	3.66e-01	2.71e-04



Evaluating how well AC10Med genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC10Med	GS2	0.60	-0.63	0.78	-0.18	1.97
GS2	AC10Med	0.40	-0.24	-2.93	-0.76	-3.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC10Med	GS2	0.00	-1.22	-0.27	-0.98	-0.07
GS2	AC10Med	0.00	-0.53	-0.82	-0.79	-1.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC10Med	119	113	env;DEFB117;DEFB108P1;DEFB109B;PRSS2;DEFB130B
GS2	29	27	LOC100131289;WNT3