Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC10Med	GS1	8.28e-03	9.49e-01	3.42e-03	2.16e-01
GS1	AC10Med	3.85e-06	8.97e-04	2.16e-01	8.92e-08



Evaluating how well AC10Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC10Med	GS1	0.62	-1.29	-0.39	-1.57	1.76
GS1	AC10Med	0.37	-2.78	-4.10	-0.95	-4.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC10Med	GS1	0.00	-1.16	-1.31	-1.22	0.28
GS1	AC10Med	0.00	-1.73	-1.85	-0.62	-1.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC10Med	119	113	DEFB108P1;DEFB130B;env;DEFB117;PRSS2;DEFB109B
GS1	20	20