Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4Med	GS1	7.22e-01	6.68e-01	3.20e-03	1.08e-04
GS1	AC4Med	1.16e-02	9.15e-01	6.67e-10	1.36e-06



Evaluating how well AC4Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4Med	GS1	0.74	-0.04	0.43	0.54	3.57
GS1	AC4Med	0.62	-0.54	-0.02	0.19	6.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4Med	GS1	0.00	-1.55	-0.70	-0.41	1.08
GS1	AC4Med	0.01	-0.72	0.74	0.53	4.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4Med	184	179	CRMA;ORF71;SPI-2;MC159L;UGT2A1
GS1	20	20