Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4Med	GS2	3.11e-01	7.20e-01	5.76e-02	1.12e-01
GS2	AC4Med	1.01e-01	2.73e-02	1.25e-03	6.78e-05



Evaluating how well AC4Med genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4Med	GS2	0.60	-0.57	-0.76	-0.31	1.89
GS2	AC4Med	0.60	-1.44	-1.10	-0.45	4.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4Med	GS2	0.00	-0.86	-0.80	-0.52	0.78
GS2	AC4Med	0.01	-0.83	0.59	0.09	3.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4Med	184	179	UGT2A1;MC159L;SPI-2;ORF71;CRMA
GS2	29	27	LOC100131289;WNT3