Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1	GS1	3.98e-01	1.13e-02	9.53e-02	2.02e-05
GS1	AC1	1.09e-01	1.67e-03	7.02e-12	4.71e-08



Evaluating how well AC1 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS1	0.78	1.48	2.83	1.47	3.89
GS1	AC1	0.69	1.66	4.77	1.25	5.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS1	0.00	0.36	1.73	0.84	2.42
GS1	AC1	0.01	0.76	4.53	0.35	4.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1	90	88	UGDH;UGT2A1
GS1	20	20