Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1	GS1	4.53e-02	1.43e-01	1.04e-01	2.58e-03
GS1	AC1	6.47e-02	2.61e-02	1.01e-09	9.26e-05



Evaluating how well AC1 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS1	0.73	0.46	1.80	0.63	3.22
GS1	AC1	0.66	0.90	3.22	0.97	4.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS1	0.00	0.11	1.03	0.55	1.52
GS1	AC1	0.01	1.20	2.47	0.77	1.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1	67	67	
GS1	20	20