Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2	GS1	7.13e-02	4.97e-01	2.22e-01	5.36e-03
GS1	AC2	3.02e-01	9.36e-02	3.08e-07	3.50e-03



Evaluating how well AC2 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2	GS1	0.70	0.17	1.19	0.25	3.28
GS1	AC2	0.62	0.90	2.14	0.61	3.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2	GS1	0.00	0.11	0.77	0.34	1.50
GS1	AC2	0.00	0.47	1.30	0.17	1.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2	67	65	UGT2A1;UGT2A3
GS1	20	20