Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC3	GS1	3.55e-02	4.08e-01	3.46e-02	2.35e-02
GS1	AC3	2.09e-01	1.19e-01	1.74e-19	1.38e-04



Evaluating how well AC3 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3	GS1	0.69	-0.01	1.29	-0.45	2.87
GS1	AC3	0.57	1.40	1.71	0.60	3.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3	GS1	0.00	-0.30	0.55	-0.59	1.74
GS1	AC3	0.01	0.98	1.13	0.22	0.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC3	153	152	UGT2A1
GS1	20	20