Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4	GS1	1.99e-02	4.48e-01	8.02e-02	7.33e-03
GS1	AC4	1.10e-01	1.04e-01	4.24e-26	4.84e-07



Evaluating how well AC4 genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4	GS1	0.70	-0.26	1.25	-0.21	2.98
GS1	AC4	0.56	1.08	0.74	0.19	2.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4	GS1	0.00	-0.89	0.27	-0.92	0.89
GS1	AC4	0.01	0.67	-0.19	-0.28	0.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4	194	193	UGT2A1
GS1	20	20