Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1	GS2	4.11e-03	8.64e-01	3.46e-02	3.66e-02
GS2	AC1	1.88e-01	1.29e-02	2.46e-01	1.16e-01



Evaluating how well AC1 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS2	0.60	-0.11	0.11	0.07	1.98
GS2	AC1	0.52	-0.58	-2.14	-0.65	0.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS2	0.00	-0.34	-0.20	-0.25	-0.09
GS2	AC1	0.00	-0.30	-1.20	-0.46	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1	67	66	MLKL
GS2	29	27	LOC100131289;WNT3