Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2	GS2	1.96e-02	7.17e-01	1.66e-01	2.63e-02
GS2	AC2	7.22e-02	1.18e-02	2.78e-01	4.07e-01



Evaluating how well AC2 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2	GS2	0.61	-0.01	-0.03	0.18	1.86
GS2	AC2	0.49	-1.11	-2.72	-0.73	-0.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2	GS2	0.00	-0.69	-0.67	-0.50	0.15
GS2	AC2	0.00	-0.67	-1.99	-0.56	-0.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2	67	65	UGT2A3;UGT2A1
GS2	29	27	LOC100131289;WNT3