Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4	GS2	5.26e-04	8.54e-01	3.68e-03	2.64e-01
GS2	AC4	7.39e-03	1.74e-06	7.38e-02	3.79e-03



Evaluating how well AC4 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4	GS2	0.56	-2.04	-0.49	-1.54	1.15
GS2	AC4	0.46	-1.43	-5.33	-1.48	-1.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4	GS2	0.00	-1.22	-0.77	-1.41	-0.09
GS2	AC4	0.01	-0.56	-3.32	-0.87	-1.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4	194	193	UGT2A1
GS2	29	27	WNT3 ;LOC100131289