Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC3	GS2	2.78e-03	5.88e-01	1.68e-02	5.76e-02
GS2	AC3	1.33e-01	6.44e-03	4.12e-05	1.00e-02



Evaluating how well AC3 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3	GS2	0.59	-0.84	-0.27	-0.47	1.51
GS2	AC3	0.48	-0.81	-3.62	-0.92	-0.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC3	GS2	0.00	-0.98	-0.85	-1.17	0.14
GS2	AC3	0.01	-0.61	-1.88	-0.53	-1.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC3	153	152	UGT2A1
GS2	29	27	WNT3 ;LOC100131289