Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1	GS2	4.66e-03	7.81e-01	2.54e-02	7.37e-02
GS2	AC1	1.35e-01	1.22e-02	6.09e-01	9.29e-02



Evaluating how well AC1 genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS2	0.60	-0.11	0.12	0.04	1.78
GS2	AC1	0.52	-0.65	-2.11	-0.87	0.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1	GS2	0.00	-0.39	-0.21	-0.22	0.36
GS2	AC1	0.00	-0.46	-1.20	-0.56	-0.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1	67	66	MLKL
GS2	29	27	WNT3 ;LOC100131289