Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2 Exclusive	GS3	1.36e-04	8.88e-01	1.23e-02	3.70e-02
GS3 Exclusive	AC2	4.00e-02	7.17e-03	6.61e-01	2.14e-01
AC2 Exclusive	GS3 Exclusive	1.01e-04	9.82e-01	1.85e-02	6.31e-02
GS3 Exclusive	AC2 Exclusive	9.94e-02	7.27e-03	6.09e-01	3.53e-01
AC2 Exclusive	Overlap	9.92e-02	1.18e-01	9.92e-02	1.41e-01
GS3 Exclusive	Overlap	7.14e-01	5.50e-01	7.54e-01	4.17e-01
Overlap	Exclusives	3.23e-06	8.58e-09	1.55e-03	6.59e-11



Evaluating how well AC2 genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2 Exclusive	GS3	0.58	0.01	0.44	0.05	2.43
GS3 Exclusive	AC2	0.49	-0.86	-2.59	-0.79	-0.32
AC2 Exclusive	GS3 Exclusive	0.58	-0.15	0.00	0.09	2.10
GS3 Exclusive	AC2 Exclusive	0.49	-0.60	-2.81	-0.57	-0.13
AC2 Exclusive	Overlap	0.97	2.12	2.27	1.72	1.40
GS3 Exclusive	Overlap	0.24	-0.41	-0.77	-0.65	-0.77
Overlap	Exclusives	0.69	1.74	6.76	1.94	8.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2 Exclusive	GS3	0.00	-0.33	0.27	-0.08	1.40
GS3 Exclusive	AC2	0.00	-0.62	-1.52	-0.47	-0.53
AC2 Exclusive	GS3 Exclusive	0.00	-0.54	-0.29	-0.24	0.26
GS3 Exclusive	AC2 Exclusive	0.00	-0.42	-1.49	-0.31	-0.36
AC2 Exclusive	Overlap	0.00	3.46	2.38	1.02	0.37
GS3 Exclusive	Overlap	0.00	-0.26	-0.38	-0.23	-0.15
Overlap	Exclusives	0.02	3.09	21.36	2.72	12.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2 Exclusive	67	66	UGT2A1
GS3 Exclusive	78	77	CASC16
Overlap	1	1