Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC4 Exclusive	GS3	7.45e-06	8.30e-01	4.33e-04	9.57e-02
GS3 Exclusive	AC4	8.51e-02	4.96e-02	9.08e-03	3.22e-02
AC4 Exclusive	GS3 Exclusive	6.70e-06	9.28e-01	2.00e-04	1.48e-01
GS3 Exclusive	AC4 Exclusive	1.41e-01	6.50e-02	1.71e-02	2.75e-02
AC4 Exclusive	Overlap	9.92e-02	1.05e-01	9.92e-02	1.66e-01
GS3 Exclusive	Overlap	7.73e-01	8.11e-01	7.73e-01	3.51e-01
Overlap	Exclusives	9.16e-11	4.99e-12	7.09e-04	1.77e-12



Evaluating how well AC4 genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4 Exclusive	GS3	0.57	-1.12	0.55	-0.54	2.32
GS3 Exclusive	AC4	0.52	0.60	-1.44	-0.22	0.94
AC4 Exclusive	GS3 Exclusive	0.56	-1.27	0.32	-0.85	1.79
GS3 Exclusive	AC4 Exclusive	0.52	0.55	-1.33	-0.29	1.05
AC4 Exclusive	Overlap	0.95	1.94	1.85	1.96	1.50
GS3 Exclusive	Overlap	0.24	-0.45	-0.50	-0.63	-0.90
Overlap	Exclusives	0.66	1.53	7.05	1.43	10.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC4 Exclusive	GS3	0.01	-0.80	0.95	-0.46	1.92
GS3 Exclusive	AC4	0.01	0.51	-0.63	-0.11	0.17
AC4 Exclusive	GS3 Exclusive	0.00	-1.08	0.50	-0.71	0.35
GS3 Exclusive	AC4 Exclusive	0.01	0.25	-0.51	-0.16	0.31
AC4 Exclusive	Overlap	0.00	3.08	3.48	0.79	1.52
GS3 Exclusive	Overlap	0.00	-0.22	-0.25	-0.29	-0.28
Overlap	Exclusives	0.04	3.60	23.41	2.45	20.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC4 Exclusive	193	192	UGT2A1
GS3 Exclusive	78	77	CASC16
Overlap	1	1