Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1 Exclusive	GS3	3.32e-04	7.58e-01	3.25e-02	1.16e-02
GS3 Exclusive	AC1	1.89e-02	2.22e-02	4.74e-01	7.08e-02
AC1 Exclusive	GS3 Exclusive	5.36e-05	7.68e-01	1.53e-02	1.25e-02
GS3 Exclusive	AC1 Exclusive	2.65e-02	3.82e-02	4.31e-01	5.89e-02
AC1 Exclusive	Overlap	9.92e-02	1.12e-01	9.92e-02	1.33e-01
GS3 Exclusive	Overlap	7.34e-01	7.14e-01	5.70e-01	4.17e-01
Overlap	Exclusives	7.62e-06	5.34e-07	9.16e-03	5.05e-10



Evaluating how well AC1 genes are linked to GS3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1 Exclusive	GS3	0.59	0.34	0.69	0.42	2.59
GS3 Exclusive	AC1	0.53	-0.71	-1.98	-0.53	0.82
AC1 Exclusive	GS3 Exclusive	0.58	-0.16	0.33	0.15	2.59
GS3 Exclusive	AC1 Exclusive	0.53	-0.65	-1.33	-0.48	1.09
AC1 Exclusive	Overlap	0.98	2.63	1.71	2.32	1.61
GS3 Exclusive	Overlap	0.24	-0.54	-0.57	-0.82	-0.85
Overlap	Exclusives	0.69	1.90	6.16	1.71	8.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1 Exclusive	GS3	0.01	-0.11	0.52	0.26	1.15
GS3 Exclusive	AC1	0.00	-0.44	-0.96	-0.38	0.25
AC1 Exclusive	GS3 Exclusive	0.00	-0.52	-0.04	-0.07	0.36
GS3 Exclusive	AC1 Exclusive	0.00	-0.41	-0.69	-0.37	-0.03
AC1 Exclusive	Overlap	0.00	8.05	3.31	5.20	2.09
GS3 Exclusive	Overlap	0.00	-0.39	-0.26	-0.35	-0.17
Overlap	Exclusives	0.02	4.90	21.34	6.04	14.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1 Exclusive	66	65	MLKL
GS3 Exclusive	78	77	CASC16
Overlap	1	1