Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1Med	GS1	1.51e-01	4.76e-01	4.71e-02	6.30e-04
GS1	AC1Med	7.03e-01	1.74e-03	3.10e-10	8.55e-10



Evaluating how well AC1Med genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Med	GS1	0.75	0.91	1.03	1.05	3.68
GS1	AC1Med	0.69	0.62	3.41	1.25	5.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Med	GS1	0.00	-0.14	-1.19	0.79	0.17
GS1	AC1Med	0.01	0.01	2.60	1.34	6.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1Med	95	93	ORF71;MC159L
GS1	20	20