Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
testgp1 Exclusive	testgp2	7.08e-02	2.48e-01	1.07e-01	1.56e-10
testgp2 Exclusive	testgp1	5.03e-06	6.81e-01	3.07e-03	2.32e-01
testgp1 Exclusive	testgp2 Exclusive	1.42e-01	4.35e-01	2.87e-01	1.81e-08
testgp2 Exclusive	testgp1 Exclusive	3.64e-06	6.44e-01	4.70e-03	1.72e-01
testgp1 Exclusive	Overlap	4.17e-02	1.40e-01	3.37e-01	8.48e-04
testgp2 Exclusive	Overlap	1.02e-02	1.02e-02	2.34e-04	1.35e-03
Overlap	Exclusives	3.55e-04	4.64e-04	6.13e-39	5.52e-05



Evaluating how well testgp1 genes are linked to testgp2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
testgp1 Exclusive	testgp2	0.77	1.37	2.56	0.79	6.50
testgp2 Exclusive	testgp1	0.48	0.37	-0.54	-0.22	-1.39
testgp1 Exclusive	testgp2 Exclusive	0.76	1.31	1.93	0.92	6.81
testgp2 Exclusive	testgp1 Exclusive	0.47	0.48	-0.70	-0.61	-1.49
testgp1 Exclusive	Overlap	0.93	1.90	1.75	1.54	2.99
testgp2 Exclusive	Overlap	0.98	1.20	2.19	2.33	3.28
Overlap	Exclusives	0.56	3.35	4.06	3.52	4.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
testgp1 Exclusive	testgp2	0.01	0.53	-0.21	-0.60	11.97
testgp2 Exclusive	testgp1	0.02	4.03	1.66	1.28	0.46
testgp1 Exclusive	testgp2 Exclusive	0.01	0.41	-0.56	-0.67	1.72
testgp2 Exclusive	testgp1 Exclusive	0.01	1.71	0.18	-0.24	-0.89
testgp1 Exclusive	Overlap	0.00	1.78	0.41	0.33	0.63
testgp2 Exclusive	Overlap	0.03	7.09	77.73	51.57	15.90
Overlap	Exclusives	0.04	13.06	19.38	12.83	17.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
testgp1 Exclusive	288	282	;SSPO;GAGE2C;TNFAIP8L2-SCNM1;C4B_2;GAGE2B
testgp2 Exclusive	56	56	
Overlap	4	4