Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	GS	9.00e-01	4.93e-01	9.27e-01	4.41e-03
GS	EAML	6.94e-01	4.80e-01	2.52e-22	4.12e-01



Evaluating how well EAML genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	GS	0.80	0.56	1.73	0.60	3.17
GS	EAML	0.48	0.48	-0.14	-0.05	-1.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	GS	0.00	-0.10	1.49	-0.23	1.31
GS	EAML	0.01	1.78	0.46	0.25	-0.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	207	205	PNMA6F;AL133500.1
GS	12	11	Parkin