Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	GS	3.11e-01	6.85e-01	4.09e-01	5.37e-03
GS	EPI	7.15e-01	8.68e-01	1.42e-12	3.13e-01



Evaluating how well EPI genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	GS	0.72	-0.57	0.16	-0.19	2.29
GS	EPI	0.47	0.15	-0.25	-0.15	-1.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	GS	0.00	-0.72	-0.43	-0.63	0.90
GS	EPI	0.01	0.06	-0.52	-0.40	-0.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	128	127	AC010255.3
GS	12	11	Parkin