Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet	GS1	7.27e-01	8.89e-01	3.45e-04	6.07e-04
GS1	wavelet	1.65e-02	1.25e-01	9.38e-33	2.62e-28



Evaluating how well wavelet genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet	GS1	0.85	1.12	1.12	1.47	3.94
GS1	wavelet	0.73	0.31	2.29	1.34	13.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet	GS1	0.00	-0.98	-2.83	0.72	4.49
GS1	wavelet	0.02	0.18	0.96	2.23	12.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet	243	243	
GS1	12	11	Parkin